Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2011
[Extracorporeal cardiac shock wave therapy improved myocardial micro-vascular circulation after acute myocardial infarction at early stage in pigs].
Аннотация на английскомСтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Tao Si-ming, Guo Tao, Wang Yue, Cai Hong-yan, Yang Chao
Аннотация
OBJECTIVE: To explore the effect of low-energy extracorporeal shock wave therapy to improve myocardial micro-vascular circulation after acute myocardial infarction at the early stage in pig model.
METHODS: A total of 25 domestic pigs were used in this study. Model of acute myocardial infarction (AMI) was created successfully by the implantation of angioplasty balloon in mid-distal segment of left anterior descending coronary artery (n=20). These AMI animals were divided two groups. Extracorporeal shock wave therapy to the ischemic myocardial region was performed for the group of shock wave therapy (n=15) at 3 days after acute myocardial infarction; The remaining AMI animals were treated in the same manner, but without the shock wave therapy (n=5), The other health animals (n=5) were used as blank control group. The number of endothelium cell, capillary density, VEGF mRNA level and collateral vessel Rentrop score in each group were evaluated and compared.
RESULTS: Shock wave treatment up-regulated the mRNA expression of VEGF in the model of acute myocardial infarction (P < 0.05). Furthermore, the number of capillaries was significantly higher in the shock wave group than that of positive and blank control group (P < 0.05). The Rentrop score of collateral vessel indicated the reconstruction of collateral circulation in shock wave group.
CONCLUSION: Extracorporeal cardiac shock wave therapy could effectively induce angiogenesis, up-regulate the expression of angiogenic factor, resulting in an improvement in micro-vascular circulation reconstruction of ischemic myocardial region.
METHODS: A total of 25 domestic pigs were used in this study. Model of acute myocardial infarction (AMI) was created successfully by the implantation of angioplasty balloon in mid-distal segment of left anterior descending coronary artery (n=20). These AMI animals were divided two groups. Extracorporeal shock wave therapy to the ischemic myocardial region was performed for the group of shock wave therapy (n=15) at 3 days after acute myocardial infarction; The remaining AMI animals were treated in the same manner, but without the shock wave therapy (n=5), The other health animals (n=5) were used as blank control group. The number of endothelium cell, capillary density, VEGF mRNA level and collateral vessel Rentrop score in each group were evaluated and compared.
RESULTS: Shock wave treatment up-regulated the mRNA expression of VEGF in the model of acute myocardial infarction (P < 0.05). Furthermore, the number of capillaries was significantly higher in the shock wave group than that of positive and blank control group (P < 0.05). The Rentrop score of collateral vessel indicated the reconstruction of collateral circulation in shock wave group.
CONCLUSION: Extracorporeal cardiac shock wave therapy could effectively induce angiogenesis, up-regulate the expression of angiogenic factor, resulting in an improvement in micro-vascular circulation reconstruction of ischemic myocardial region.