Journal of medical and veterinary mycology : bi-monthly publication of the International Society for Human and Animal Mycology · 1986
Inhibition of cellular immunity by products of Aspergillus fumigatus.
Сравнительное исследованиеСтатьяНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Chaparas S D, Morgan P A, Holobaugh P, Kim S J
Аннотация
A fraction, FB, from extracts of Aspergillus fumigatus which previously was found to display a high degree of cellular hypersensitivity in skin tests in sensitized guinea-pigs but a low ability to affect transformation of lymphocytes in vitro, was studied. This fraction was found to be capable of inhibiting lymphocyte transformation induced in vitro by tuberculin and by T and B cell mitogens. The inhibitory properties of FB on lymphocyte activation were heat labile, destroyed by proteolysis, and could be reversed by washing 24 h after addition. Antibody to FB did not reduce inhibition of lymphocyte transformation. Fluorescence labeling studies showed a uniform and non-capping distribution of FB on lymphocyte surfaces which resulted in exclusion of attachment of fluorescein-labeled Concanavalin A to the cell surface.