Sensitization in traumatized skin.

Patch tests with the standard series of chemical allergens were performed on 8,230 patients having various dermatoses. The frequency of contact sensitization among categories of dermatoses varied markedly. While only 21% of persons whose diagnosis was occupational contact dermatitis reacted allergically to at least one chemical, reactions were observed in 70% of those whose skin had been damaged by mechanical traumas. Cuts, wounds, and abrasions incurred on the job, while not very serious injuries per se, should be regarded as having greater clinical importance insofar as they increase the likelihood of contact sensitization to allergens.