[Role of the pituitary gland in the sex differentiation of the level of corticosteroid-binding globulin in rats].

A study was made of the role of hypophyseal hormones in the regulation of the sex-associated level of corticosteroid-binding globulin (CBG) in the serum of female and male rats. Pituitary body removal did not change the level of CBG in males but caused its decrease in females to the level in intact males. Ectopic transplantation of the homologous pituitary body under the renal capsule increased the level of CBG in animals of both sexes. Intermittent infusion of STH did not change CBG content in hypophysectomized female rats and lowered it in intact females. A negative effect of androgens on the studied sign did not manifest itself either against a background of hypophysectomy or hypophyseal ectopy. Corticosteroids and thyroid hormones preserved their effects with regard to the level of CBG in hypophysectomized rats.