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DOI 10.1126/sciimmunol.abp8966

Медицинская библиотека · Science immunology · 2023

Vaccine breakthrough hypoxemic COVID-19 pneumonia in patients with auto-Abs neutralizing type I IFNs.

Bastard Paul, Vazquez Sara E, Liu Jamin, Laurie Matthew T, Wang Chung Yu, Gervais Adrian, Le Voyer Tom, Bizien Lucy, Zamecnik Colin, Philippot Quentin, Rosain Jérémie, Catherinot Emilie, Willmore Andrew, Mitchell Anthea M, Bair Rebecca, Garçon Pierre, Kenney Heather, Fekkar Arnaud, Salagianni Maria, Poulakou Garyphallia, Siouti Eleni, Sahanic Sabina, Tancevski Ivan, Weiss Günter, Nagl Laurenz, Manry Jérémy, Duvlis Sotirija, Arroyo-Sánchez Daniel, Paz Artal Estela, Rubio Luis, Perani Cristiano, Bezzi Michela, Sottini Alessandra, Quaresima Virginia, Roussel Lucie, Vinh Donald C, Reyes Luis Felipe, Garzaro Margaux, Hatipoglu Nevin, Boutboul David, Tandjaoui-Lambiotte Yacine, Borghesi Alessandro, Aliberti Anna, Cassaniti Irene, Venet Fabienne, Monneret Guillaume, Halwani Rabih, Sharif-Askari Narjes Saheb, Danielson Jeffrey, Burrel Sonia, Morbieu Caroline, Stepanovskyy Yurii, Bondarenko Anastasia, Volokha Alla, Boyarchuk Oksana, Gagro Alenka, Neuville Mathilde, Neven Bénédicte, Keles Sevgi, Hernu Romain, Bal Antonin, Novelli Antonio, Novelli Giuseppe, Saker Kahina, Ailioaie Oana, Antolí Arnau, Jeziorski Eric, Rocamora-Blanch Gemma, Teixeira Carla, Delaunay Clarisse, Lhuillier Marine, Le Turnier Paul, Zhang Yu, Mahevas Matthieu, Pan-Hammarström Qiang, Abolhassani Hassan, Bompoil Thierry, Dorgham Karim, COVID HGE Consortium, French COVID Study Group, COMET Consortium, Gorochov Guy, Laouenan Cédric, Rodríguez-Gallego Carlos, Ng Lisa F P, Renia Laurent, Pujol Aurora, Belot Alexandre, Raffi François, Allende Luis M, Martinez-Picado Javier, Ozcelik Tayfun, Imberti Luisa, Notarangelo Luigi D, Troya Jesus, Solanich Xavier, Zhang Shen-Ying, Puel Anne, Wilson Michael R, Trouillet-Assant Sophie, Abel Laurent, Jouanguy Emmanuelle, Ye Chun Jimmie, Cobat Aurélie, Thompson Leslie M, Andreakos Evangelos, Zhang Qian, Anderson Mark S, Casanova Jean-Laurent, DeRisi Joseph L

СтатьяПоддержка NIH: внешняя программаПоддержка исследования: вне правительства СШАПеревод пока не подготовлен

Аннотация

Life-threatening "breakthrough" cases of critical COVID-19 are attributed to poor or waning antibody (Ab) response to SARS-CoV-2 vaccines in individuals already at risk. Preexisting auto-Abs neutralizing type I IFNs underlie at least 15% of critical COVID-19 pneumonia cases in unvaccinated individuals; their contribution to hypoxemic breakthrough cases in vaccinated people is unknown. We studied a cohort of 48 individuals (aged 20 to 86 years) who received two doses of a messenger RNA (mRNA) vaccine and developed a breakthrough infection with hypoxemic COVID-19 pneumonia 2 weeks to 4 months later. Ab levels to the vaccine, neutralization of the virus, and auto-Abs to type I IFNs were measured in the plasma. Forty-two individuals had no known deficiency of B cell immunity and a normal Ab response to the vaccine. Among them, 10 (24%) had auto-Abs neutralizing type I IFNs (aged 43 to 86 years). Eight of these 10 patients had auto-Abs neutralizing both IFN-α2 and IFN-ω, whereas two neutralized IFN-ω only. No patient neutralized IFN-β. Seven neutralized type I IFNs at 10 ng/ml and three at 100 pg/ml only. Seven patients neutralized SARS-CoV-2 D614G and Delta efficiently, whereas one patient neutralized Delta slightly less efficiently. Two of the three patients neutralizing only type I IFNs at 100 pg/ml neutralized both D614G and Delta less efficiently. Despite two mRNA vaccine inoculations and the presence of circulating Abs capable of neutralizing SARS-CoV-2, auto-Abs neutralizing type I IFNs may underlie a notable proportion of hypoxemic COVID-19 pneumonia cases, highlighting the importance of this particularly vulnerable population.

Для цитирования: Bastard Paul, Vazquez Sara E, Liu Jamin, Laurie Matthew T, Wang Chung Yu, Gervais Adrian, Le Voyer Tom, Bizien Lucy, Zamecnik Colin, Philippot Quentin, Rosain Jérémie, Catherinot Emilie, Willmore Andrew, Mitchell Anthea M, Bair Rebecca, Garçon Pierre, Kenney Heather, Fekkar Arnaud, Salagianni Maria, Poulakou Garyphallia, Siouti Eleni, Sahanic Sabina, Tancevski Ivan, Weiss Günter, Nagl Laurenz, Manry Jérémy, Duvlis Sotirija, Arroyo-Sánchez Daniel, Paz Artal Estela, Rubio Luis, Perani Cristiano, Bezzi Michela, Sottini Alessandra, Quaresima Virginia, Roussel Lucie, Vinh Donald C, Reyes Luis Felipe, Garzaro Margaux, Hatipoglu Nevin, Boutboul David, Tandjaoui-Lambiotte Yacine, Borghesi Alessandro, Aliberti Anna, Cassaniti Irene, Venet Fabienne, Monneret Guillaume, Halwani Rabih, Sharif-Askari Narjes Saheb, Danielson Jeffrey, Burrel Sonia, Morbieu Caroline, Stepanovskyy Yurii, Bondarenko Anastasia, Volokha Alla, Boyarchuk Oksana, Gagro Alenka, Neuville Mathilde, Neven Bénédicte, Keles Sevgi, Hernu Romain, Bal Antonin, Novelli Antonio, Novelli Giuseppe, Saker Kahina, Ailioaie Oana, Antolí Arnau, Jeziorski Eric, Rocamora-Blanch Gemma, Teixeira Carla, Delaunay Clarisse, Lhuillier Marine, Le Turnier Paul, Zhang Yu, Mahevas Matthieu, Pan-Hammarström Qiang, Abolhassani Hassan, Bompoil Thierry, Dorgham Karim, COVID HGE Consortium, French COVID Study Group, COMET Consortium, Gorochov Guy, Laouenan Cédric, Rodríguez-Gallego Carlos, Ng Lisa F P, Renia Laurent, Pujol Aurora, Belot Alexandre, Raffi François, Allende Luis M, Martinez-Picado Javier, Ozcelik Tayfun, Imberti Luisa, Notarangelo Luigi D, Troya Jesus, Solanich Xavier, Zhang Shen-Ying, Puel Anne, Wilson Michael R, Trouillet-Assant Sophie, Abel Laurent, Jouanguy Emmanuelle, Ye Chun Jimmie, Cobat Aurélie, Thompson Leslie M, Andreakos Evangelos, Zhang Qian, Anderson Mark S, Casanova Jean-Laurent, DeRisi Joseph L. Vaccine breakthrough hypoxemic COVID-19 pneumonia in patients with auto-Abs neutralizing type I IFNs.. Science immunology. 2023. DOI: 10.1126/sciimmunol.abp8966.

Предметные рубрики MeSH

HumansCOVID-19COVID-19 VaccinesSARS-CoV-2VaccinesVaccinationInterferon Type IRNA, Messenger
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