The Journal of dermatological treatment · 2011
Topical dose justification: benzoyl peroxide concentrations.
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Brandstetter Andreas J, Maibach Howard I
Аннотация
BACKGROUND: Benzoyl peroxide (BPO) is widely utilized in acne treatment as an alternative to antibiotics against which Propionibacterium acnes becomes more resistant.
OBJECTIVE: This overview examines BPO dose justification.
METHODS: PubMed, Embase® and Science Citation Index searches were conducted using the keywords "benzoyl peroxide" and "acne vulgaris".
RESULTS: Limited experimental data are available. However, there appears no significant difference in the efficacy of concentrations from 2.5% to 10%.
DISCUSSION: The extent of free fatty acids and the percutaneous penetration of BPO may not play a critical role in acne vulgaris.
OBJECTIVE: This overview examines BPO dose justification.
METHODS: PubMed, Embase® and Science Citation Index searches were conducted using the keywords "benzoyl peroxide" and "acne vulgaris".
RESULTS: Limited experimental data are available. However, there appears no significant difference in the efficacy of concentrations from 2.5% to 10%.
DISCUSSION: The extent of free fatty acids and the percutaneous penetration of BPO may not play a critical role in acne vulgaris.