Unusual Colonic Iron Deposition Following Prophylactic Supplementation in an Infant: A Case Report.

Iron plays a vital role in physiological functions, and its deposition is typically limited to reticuloendothelial tissues in the presence of excess levels. We report a rare case of colonic iron deposition in a 13-month-old child without iron overload or toxicity. Despite a normal serum iron profile and administration of only prophylactic iron supplementation, histological examination revealed marked iron accumulation in the lamina propria of the colon. This unusual presentation emphasizes the need for awareness of possible iron-related mucosal changes even in the absence of systemic overload, particularly in children with gastrointestinal or immunologic comorbidities.