Beyond beta rhythms: subthalamic aperiodic broadband power scales with Parkinson's disease severity-a cross-sectional multicentre study.
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Gerster Moritz, Waterstraat Gunnar, Binns Thomas S, Darcy Natasha, Wiest Christoph, Köhler Richard M, Vanhoecke Jojo, West Timothy O, Sure Matthias, Todorov Dmitrii, Radzinski Lukasz, Habets Jeroen, Busch Johannes L, Feldmann Lucia K, Krause Patricia, Faust Katharina, Schneider Gerd-Helge, Ashkan Keyoumars, Pereira Erlick, Akram Harith, Zrinzo Ludvic, Blankertz Benjamin, Villringer Arno, Tan Huiling, Hirschmann Jan, Kühn Andrea A, Florin Esther, Schnitzler Alfons, Oswal Ashwini, Litvak Vladimir, Neumann Wolf-Julian, Curio Gabriel, Nikulin Vadim
Аннотация
METHODS: We analysed subthalamic local field potentials from 119 patients with Parkinson's disease (31 female; mean age 60 ± 9 years) across five independent datasets. Power spectra were parametrised and studied in relation to Levodopa administration and the severity of motor symptoms.
FINDINGS: Our findings suggest that small sample sizes contributed to the variable correlations between beta power and motor symptoms reported in previous studies. Here, we demonstrate that more than 100 patients are required for stable replication. Aperiodic offset and low gamma (30-45 Hz) oscillations were negatively correlated with motor deficits (rOffset=-0.32, p=4e-4; rLγ=-0.21, p=0.021), whereas low beta oscillations were positively correlated (rLβ=0.24, p=0.010). Combining offset, low beta, and low gamma power (rLin.reg.(Offset,Lβ,Lγ)=0.47, p=1e-4) explained significantly more variance in symptom severity than low beta alone (J-test: p=2e-5). Interhemispheric within-patient analyses showed that, unlike beta oscillations, aperiodic broadband power (2-60 Hz)-likely reflecting spiking activity-was increased in the more affected hemisphere (Levodopa off-state: p=0.015; on-state: p=0.005).
INTERPRETATION: Spectral features beyond conventional beta rhythms are critical to understanding Parkinson's pathophysiology. Aperiodic broadband power shows potential as a new biomarker for adaptive deep brain stimulation, providing important insights into the relationship between subthalamic hyperactivity and motor symptoms in Parkinson's disease.
FUNDING: This work was supported by Deutsche Forschungsgemeinschaft (German Research Foundation) Project ID 424778381 TRR 295 "ReTune". H.A. is supported by NIHR UCLH BRC. This work was supported by an MRC Clinician Scientist Fellowship (MR/W024810/1) held by A.O. W.-J.N. received funding from the European Union (ERC, ReinforceBG, project 101077060). E.F. received funding from the Volkswagen foundation (Lichtenberg program 89387). G.W. and L.R. received funding from Deutsche Forschungsgemeinschaft Project ID 511192033.