Atrial Fibrillation Ablation in Heart Failure with Preserved Ejection Fraction.

Catheter ablation (CA) for atrial fibrillation (AF) in patients with heart failure with preserved ejection fraction (HFpEF) addresses the significant overlap of these conditions, often found in patients with comorbidities such as obesity, diabetes, and hypertension. HFpEF is characterized by diastolic dysfunction, leading to high left atrial pressures and atrial remodeling, which promotes AF. While treatments for HFpEF are limited, recent studies suggest CA can reduce AF burden, improve quality-of-life, and lower hospitalization rates. Current and upcoming randomized trials aim to establish CA's role as a first-line therapy for AF in HFpEF, potentially transforming patient outcomes.