The Journal of nutrition · 2025
Dietary Supplementation with Six Percent Blueberries (Vaccinium corymbosum L.) Attenuates Neurodegeneration and Motor Deficits in a Parkinson's Disease Model.
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Dawn-Ojeda Alicia Abigail, Marín-Canul Jesús Enrique, Granados-Patrón Diego Antonio, Cuevas-Carbonell Sergio Guillermo, Mut-Martín Mirza Concepción, Pérez-Izquierdo Odette, Gallegos-Tintoré Santiago Moisés, Góngora-Alfaro José Luis, Aranda-González Irma Isela
Аннотация
BACKGROUND: Parkinson disease (PD) is a progressive neurodegenerative disorder associated with oxidative stress and neuroinflammation. Blueberries (Vaccinium corymbosum L.), rich in polyphenols and anthocyanins, have shown potential in mitigating these pathological processes.
OBJECTIVES: The objective of this study was to evaluate whether dietary supplementation with 6% freeze-dried blueberries attenuates motor impairment, dopaminergic denervation, and microglial activation in a 6-hydroxydopamine (6-OHDA)-induced rat model of PD.
METHODS: Adult male Wistar rats were randomly assigned to a control group [rodent food (standard diet)] or a treatment group (6% blueberry-enriched diet). Hemiparkinsonism was induced via stereotaxic injection of 6-OHDA into the right striatum. Behavioral assessments (narrow beam test, apomorphine-induced rotations, and cylinder test) were conducted before and after surgery. Immunohistochemistry was performed to quantify tyrosine hydroxylase and ionized calcium-binding adapter molecule 1 expression in the striatum and substantia nigra. Statistical analyze included Two-way analysis of variance and Student's t tests.
RESULTS: Rats receiving 6% blueberries showed significantly fewer contralateral paw slips, reduced apomorphine-induced rotations, and lower motor asymmetry compared with controls (P < 0.05). Immunohistochemical analysis revealed decreased dopaminergic denervation and microglial activation in both brain regions. Behavioral improvements correlated with histologic outcomes.
CONCLUSIONS: A diet enriched with 6% blueberries significantly mitigated motor deficits, dopaminergic neuron loss, and microglial activation in a 6-OHDA-induced rat model of PD. These findings highlight the potential of blueberry supplementation as a neuroprotective nutritional strategy in neurodegenerative disease models.
OBJECTIVES: The objective of this study was to evaluate whether dietary supplementation with 6% freeze-dried blueberries attenuates motor impairment, dopaminergic denervation, and microglial activation in a 6-hydroxydopamine (6-OHDA)-induced rat model of PD.
METHODS: Adult male Wistar rats were randomly assigned to a control group [rodent food (standard diet)] or a treatment group (6% blueberry-enriched diet). Hemiparkinsonism was induced via stereotaxic injection of 6-OHDA into the right striatum. Behavioral assessments (narrow beam test, apomorphine-induced rotations, and cylinder test) were conducted before and after surgery. Immunohistochemistry was performed to quantify tyrosine hydroxylase and ionized calcium-binding adapter molecule 1 expression in the striatum and substantia nigra. Statistical analyze included Two-way analysis of variance and Student's t tests.
RESULTS: Rats receiving 6% blueberries showed significantly fewer contralateral paw slips, reduced apomorphine-induced rotations, and lower motor asymmetry compared with controls (P < 0.05). Immunohistochemical analysis revealed decreased dopaminergic denervation and microglial activation in both brain regions. Behavioral improvements correlated with histologic outcomes.
CONCLUSIONS: A diet enriched with 6% blueberries significantly mitigated motor deficits, dopaminergic neuron loss, and microglial activation in a 6-OHDA-induced rat model of PD. These findings highlight the potential of blueberry supplementation as a neuroprotective nutritional strategy in neurodegenerative disease models.