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DOI 10.1002/alz.12632

Медицинская библиотека · Alzheimer's & dementia : the journal of the Alzheimer's Association · 2022

Characteristics of the Ontario Neurodegenerative Disease Research Initiative cohort.

Sunderland Kelly M, Beaton Derek, Arnott Stephen R, Kleinstiver Peter, Kwan Donna, Lawrence-Dewar Jane M, Ramirez Joel, Tan Brian, Bartha Robert, Black Sandra E, Borrie Michael, Brien Donald, Casaubon Leanne K, Coe Brian C, Cornish Benjamin, Dilliott Allison A, Dowlatshahi Dar, Finger Elizabeth, Fischer Corinne, Frank Andrew, Fraser Julia, Freedman Morris, Greenberg Barry, Grimes David A, Hassan Ayman, Hatch Wendy, Hegele Robert A, Hudson Christopher, Jog Mandar, Kumar Sanjeev, Lang Anthony, Levine Brian, Lou Wendy, Mandzia Jennifer, Marras Connie, McIlroy William, Montero-Odasso Manuel, Munoz David G, Munoz Douglas P, Orange Joseph B, Park David S, Pasternak Stephen H, Pieruccini-Faria Frederico, Rajji Tarek K, Roberts Angela C, Robinson John F, Rogaeva Ekaterina, Sahlas Demetrios J, Saposnik Gustavo, Scott Christopher J M, Seitz Dallas, Shoesmith Christen, Steeves Thomas D L, Strong Michael J, Strother Stephen C, Swartz Richard H, Symons Sean, Tang-Wai David F, Tartaglia Maria Carmela, Troyer Angela K, Turnbull John, Zinman Lorne, McLaughlin Paula M, Masellis Mario, Binns Malcolm A, ONDRI Investigators

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Аннотация

INTRODUCTION

Understanding synergies between neurodegenerative and cerebrovascular pathologies that modify dementia presentation represents an important knowledge gap.

METHODS

This multi-site, longitudinal, observational cohort study recruited participants across prevalent neurodegenerative diseases and cerebrovascular disease and assessed participants comprehensively across modalities. We describe univariate and multivariate baseline features of the cohort and summarize recruitment, data collection, and curation processes.

RESULTS

We enrolled 520 participants across five neurodegenerative and cerebrovascular diseases. Median age was 69 years, median Montreal Cognitive Assessment score was 25, median independence in activities of daily living was 100% for basic and 93% for instrumental activities. Spousal study partners predominated; participants were often male, White, and more educated. Milder disease stages predominated, yet cohorts reflect clinical presentation.

DISCUSSION: Data will be shared with the global scientific community. Within-disease and disease-agnostic approaches are expected to identify markers of severity, progression, and therapy targets. Sampling characteristics also provide guidance for future study design.

Для цитирования: Sunderland Kelly M, Beaton Derek, Arnott Stephen R, Kleinstiver Peter, Kwan Donna, Lawrence-Dewar Jane M, Ramirez Joel, Tan Brian, Bartha Robert, Black Sandra E, Borrie Michael, Brien Donald, Casaubon Leanne K, Coe Brian C, Cornish Benjamin, Dilliott Allison A, Dowlatshahi Dar, Finger Elizabeth, Fischer Corinne, Frank Andrew, Fraser Julia, Freedman Morris, Greenberg Barry, Grimes David A, Hassan Ayman, Hatch Wendy, Hegele Robert A, Hudson Christopher, Jog Mandar, Kumar Sanjeev, Lang Anthony, Levine Brian, Lou Wendy, Mandzia Jennifer, Marras Connie, McIlroy William, Montero-Odasso Manuel, Munoz David G, Munoz Douglas P, Orange Joseph B, Park David S, Pasternak Stephen H, Pieruccini-Faria Frederico, Rajji Tarek K, Roberts Angela C, Robinson John F, Rogaeva Ekaterina, Sahlas Demetrios J, Saposnik Gustavo, Scott Christopher J M, Seitz Dallas, Shoesmith Christen, Steeves Thomas D L, Strong Michael J, Strother Stephen C, Swartz Richard H, Symons Sean, Tang-Wai David F, Tartaglia Maria Carmela, Troyer Angela K, Turnbull John, Zinman Lorne, McLaughlin Paula M, Masellis Mario, Binns Malcolm A, ONDRI Investigators. Characteristics of the Ontario Neurodegenerative Disease Research Initiative cohort.. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2022. DOI: 10.1002/alz.12632.

Предметные рубрики MeSH

HumansMaleAgedNeurodegenerative DiseasesActivities of Daily LivingOntarioCohort StudiesLongitudinal StudiesAlzheimer DiseaseCognitive Dysfunction
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