Zhonghua kou qiang yi xue za zhi = Zhonghua kouqiang yixue zazhi = Chinese journal of stomatology · 2006
[The role of matrix metalloproteinases and their tissue inhibitors in oral lichen planus].
Аннотация на английскомСтатьяНазвание и аннотация: Перевод пока не подготовлен
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Zhang Wei-ping, Chen Yu, Geng Ning, Tian Kun, Bao Dong-mei, Yang Ming-zhong
Аннотация
OBJECTIVE: To investigate the role of MMP-2, MT1-MMP and TIMP-2 in the carcinogenesis of oral lichen planus (OLP).
METHODS: Immunohistochemistry was performed to examine the expression of OLP and compare with that of NOM.
RESULTS: The expression of these proteinases significantly increased from NOM, non-atrophic OLP, to atrophic OLP and OSCC. The expression of MMP-2 and MT1-MMP in atrophic OLP was significantly higher than in non-atrophic OLP. Furthermore, the expression of TIMP-2 consequently increased with the increasing of the MMP, but the increase of TIMP-2 was less than that of MMP.
CONCLUSIONS: MMP may be useful marker to judge the possibility of malignant change of OLP.
METHODS: Immunohistochemistry was performed to examine the expression of OLP and compare with that of NOM.
RESULTS: The expression of these proteinases significantly increased from NOM, non-atrophic OLP, to atrophic OLP and OSCC. The expression of MMP-2 and MT1-MMP in atrophic OLP was significantly higher than in non-atrophic OLP. Furthermore, the expression of TIMP-2 consequently increased with the increasing of the MMP, but the increase of TIMP-2 was less than that of MMP.
CONCLUSIONS: MMP may be useful marker to judge the possibility of malignant change of OLP.