Digestive diseases and sciences · 2007
Liver transplantation in the setting of hepatocellular carcinoma and portal vein thrombosis: a challenging dilemma?
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Sotiropoulos Georgios C, Radtke Arnold, Schmitz Klaus J, Molmenti Ernesto P, Schroeder Tobias, Saner Fuat H, Baba Hideo A, Fouzas Ioannis, Broelsch Christoph E, Malagó Massimo, Lang Hauke
Аннотация
BACKGROUND: Portal vein thrombosis (PVT) represents a potentially unfavorable prognostic factor in liver transplantation (LT) for hepatocellular carcinoma (HCC). However, it is frequently difficult to establish preoperatively whether the thrombus is associated with tumor invasion or with stagnant flow. The purpose of this study was to further address this controversial issue.
PATIENTS AND METHODS: We evaluated 12 consecutive patients who underwent liver transplantation for HCC in the setting of PVT.
RESULTS: The origin of PVT in HCC patients could be accurately evaluated in 58% of the patients. Forty-two percent of patients had no evident portal vein invasion and only 17% of cases had tumor thrombi. One-third of patients experienced tumor recurrence within the first posttransplant year, and one-third of patients became long-term survivors (median survival of 36 months) with no evidence of tumor recurrence. One-year survival was 92%. Nine patients are currently alive after a median follow-up period of 25 months.
CONCLUSIONS: PVT in the setting of HCC is characterized by poor patient outcome. However, a respectable number of instances are not accurately evaluated preoperatively, making the decision to exclude these patients from LT sometimes a challenging dilemma.
PATIENTS AND METHODS: We evaluated 12 consecutive patients who underwent liver transplantation for HCC in the setting of PVT.
RESULTS: The origin of PVT in HCC patients could be accurately evaluated in 58% of the patients. Forty-two percent of patients had no evident portal vein invasion and only 17% of cases had tumor thrombi. One-third of patients experienced tumor recurrence within the first posttransplant year, and one-third of patients became long-term survivors (median survival of 36 months) with no evidence of tumor recurrence. One-year survival was 92%. Nine patients are currently alive after a median follow-up period of 25 months.
CONCLUSIONS: PVT in the setting of HCC is characterized by poor patient outcome. However, a respectable number of instances are not accurately evaluated preoperatively, making the decision to exclude these patients from LT sometimes a challenging dilemma.