Journal of the European Academy of Dermatology and Venereology : JEADV · 2009
Prognostic factors for cure following treatment of onychomycosis.
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Sigurgeirsson B
Аннотация
OBJECTIVE: To examine if host baseline factors and week 24 mycology results are associated with mycological and clinical cure in patients with onychomycosis treated with oral terbinafine.
DESIGN: Open pilot study to determine prognostic factors in the treatment of onychomycosis.
SETTING: Outpatient dermatology clinic.
PATIENTS: A total of 199 patients from the Icelandic arm of a trial comparing continuous terbinafine with intermittent terbinafine in onychomycosis were recruited for additional observation.
MAIN OUTCOME MEASURES: Mycological, clinical and complete cure of the target toenail 72 weeks after treatment was initiated.
RESULTS: Patients with matrix involvement or slow nail growth were less likely to reach mycological, clinical and complete cure. Lateral involvement affected complete and mycological cure rates negatively. Patients with a dermatophytoma were less likely to reach mycological cure. Patients with a history of prior infection, men and older patients were less likely to reach clinical cure. Positive culture at 24 weeks affected mycological and clinical cure at 72 weeks negatively.
LIMITATIONS: Only patients treated with terbinafine were considered.
CONCLUSIONS: Several host-related factors at baseline and positive culture at 24 weeks had negative effects on cure of onychomycosis 72 weeks after treatment was initiated. This finding merits a large study on prognostic outcome factors in onychomycosis.
DESIGN: Open pilot study to determine prognostic factors in the treatment of onychomycosis.
SETTING: Outpatient dermatology clinic.
PATIENTS: A total of 199 patients from the Icelandic arm of a trial comparing continuous terbinafine with intermittent terbinafine in onychomycosis were recruited for additional observation.
MAIN OUTCOME MEASURES: Mycological, clinical and complete cure of the target toenail 72 weeks after treatment was initiated.
RESULTS: Patients with matrix involvement or slow nail growth were less likely to reach mycological, clinical and complete cure. Lateral involvement affected complete and mycological cure rates negatively. Patients with a dermatophytoma were less likely to reach mycological cure. Patients with a history of prior infection, men and older patients were less likely to reach clinical cure. Positive culture at 24 weeks affected mycological and clinical cure at 72 weeks negatively.
LIMITATIONS: Only patients treated with terbinafine were considered.
CONCLUSIONS: Several host-related factors at baseline and positive culture at 24 weeks had negative effects on cure of onychomycosis 72 weeks after treatment was initiated. This finding merits a large study on prognostic outcome factors in onychomycosis.