[Peptide-bound oxyproline and the activity of alkaline phosphatase in the serum of women with onychodystrophy].

A clinicobiochemical analysis has revealed a relationship between the elevated peptide-bound oxyproline levels and the lower activity of alkaline phosphatase in women and the presence of the early symptom stratified nails. The degree of the elevated peptide-bound oxyproline levels is informative of the early manifestations of the damage, which is of diagnostic value and enables treatment to be used in proper time. In a group of young subjects with onychodystrophy, the significant increase of peptide-bound oxyproline with the decreased activity of alkaline phosphatase in the serum may reflect the activation of adaptive reactions. The older the organism is, the less intensity of an adaptive reaction to hypoxia that is a principal of onychodystrophy.