Journal of hepatology · 2008
Genetic factors of susceptibility and of severity in primary biliary cirrhosis.
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Poupon Raoul, Ping Chen, Chrétien Yves, Corpechot Christophe, Chazouillères Olivier, Simon Tabassome, Heath Simon C, Matsuda Fumihiko, Poupon Renée E, Housset Chantal, Barbu Véronique
Аннотация
BACKGROUND/AIMS: In primary biliary cirrhosis (PBC), pathogenesis is influenced by genetic factors that remain poorly elucidated up to now. We investigated the impact of sequence diversity in candidate genes involved in immunity (CTLA-4 and TNFalpha), in bile formation (10 hepatobiliary transporter genes) and in the adaptative response to cholestasis (three nuclear receptor genes) on the susceptibility and severity of PBC.
METHODS: A total of 42 Ht SNPs were identified and compared in 258 PBC patients and two independent groups of 286 and 269 healthy controls. All participants were white continental individuals with French ancestry.
RESULTS: Ht SNPs of CTLA-4 and TNFalpha genes were significantly associated with susceptibility to PBC. The progression rate of liver disease under ursodeoxycholic acid (UDCA) therapy was significantly linked to SNPs of TNFalpha and SLC4A2/anion exchanger 2 (AE2) genes. A multivariate Cox regression analysis including clinical and biochemical parameters showed that SLC4A2/AE2 variant was an independent prognostic factor.
CONCLUSIONS: These data point to a primary role of genes encoding regulators of the immune system in the susceptibility to PBC. They also demonstrate that allelic variations in TNFalpha and SLC4A2/AE2 have a significant impact on the evolutive profile of PBC under UDCA therapy.
METHODS: A total of 42 Ht SNPs were identified and compared in 258 PBC patients and two independent groups of 286 and 269 healthy controls. All participants were white continental individuals with French ancestry.
RESULTS: Ht SNPs of CTLA-4 and TNFalpha genes were significantly associated with susceptibility to PBC. The progression rate of liver disease under ursodeoxycholic acid (UDCA) therapy was significantly linked to SNPs of TNFalpha and SLC4A2/anion exchanger 2 (AE2) genes. A multivariate Cox regression analysis including clinical and biochemical parameters showed that SLC4A2/AE2 variant was an independent prognostic factor.
CONCLUSIONS: These data point to a primary role of genes encoding regulators of the immune system in the susceptibility to PBC. They also demonstrate that allelic variations in TNFalpha and SLC4A2/AE2 have a significant impact on the evolutive profile of PBC under UDCA therapy.
Предметные рубрики MeSH
ATP Binding Cassette Transporter, Subfamily BATP Binding Cassette Transporter, Subfamily B, Member 1AdultAgedAnion Transport ProteinsAntigens, CDAntiportersCTLA-4 AntigenCase-Control StudiesChloride-Bicarbonate AntiportersDNA-Binding ProteinsFemaleFranceGenetic Predisposition to DiseaseGenetic TestingHumansKaplan-Meier EstimateLiver Cirrhosis, BiliaryLiver X ReceptorsMaleMiddle AgedOrphan Nuclear ReceptorsPolymorphism, Single NucleotidePrognosisProportional Hazards ModelsReceptors, Cytoplasmic and NuclearSLC4A ProteinsSeverity of Illness IndexTumor Necrosis Factor-alpha