Clinical and experimental nephrology · 2008
A case of glomerulopathy showing podocytic infolding in association with Sjögren's syndrome and primary biliary cirrhosis.
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Koike Kentaro, Utsunomiya Yasunori, Ito Yoriko, Tokudome Satori, Miyazaki Yoichi, Suzuki Takahide, Okonogi Hideo, Kawamura Tetsuya, Yamada Akio, Hosoya Tatsuo, Joh Kensuke
Аннотация
A 49-year-old man was admitted to our hospital with mild proteinuria. Prior to admission, he had been diagnosed as having Sjögren's syndrome in association with primary biliary cirrhosis. Examination of a renal biopsy under light microscopy revealed diffuse and global mesangial cell proliferation and a spike and/or bubbling formation of the glomerular basement membrane (GBM), resembling membranoproliferative glomerulonephritis. In contrast, immunofluorescent studies showed marked immunoglobulin and complement depositions in the mesangial areas; however, only faint granular IgG and IgA deposition was observed along the GBM. Interestingly, electron microscopy revealed that a microtubular structure, derived from podocytes, was present in the GBM. We present a case of glomerulopathy showing podocytic infolding in association with Sjögren's syndrome and primary biliary cirrhosis.