British medical bulletin · 2014
Management of melanoma.
СтатьяПоддержка исследования: вне правительства СШАОбзорНазвание и аннотация: Перевод пока не подготовлен
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Corrie Pippa, Hategan Mirela, Fife Kate, Parkinson Christine
Аннотация
BACKGROUND: Melanoma is a potentially curable cancer, but around 20% of patients will develop disease which is beyond surgical clearance. Rising incidence alongside breakthroughs in understanding the molecular biology of this disease identifying systemic therapies offering survival gains now demand a more proactive, integrated approach to melanoma management.
SOURCES OF DATA: PubMed references relating to aspects of melanoma research and treatment.
AREAS OF AGREEMENT: Rapidly rising incidence throughout the world. Effective surgery as well as new molecular targeted systemic biological agents and immunotherapies necessitating early diagnosis and multidisciplinary therapeutic interventions.
AREAS OF CONTROVERSY: Role of screening and prevention. Benefit of interventions for locoregional melanoma, including role of sentinel lymph node biopsy. Integration and sequencing of treatments for unresectable melanoma.
GROWING POINTS: Molecular determinants of melanoma influencing disease outcome and treatment decisions.
AREAS TIMELY FOR DEVELOPING RESEARCH: Education and training of patient and healthcare professionals. Role of screening, surveillance and follow-up strategies. Biology of melanoma guiding treatment decisions.
SOURCES OF DATA: PubMed references relating to aspects of melanoma research and treatment.
AREAS OF AGREEMENT: Rapidly rising incidence throughout the world. Effective surgery as well as new molecular targeted systemic biological agents and immunotherapies necessitating early diagnosis and multidisciplinary therapeutic interventions.
AREAS OF CONTROVERSY: Role of screening and prevention. Benefit of interventions for locoregional melanoma, including role of sentinel lymph node biopsy. Integration and sequencing of treatments for unresectable melanoma.
GROWING POINTS: Molecular determinants of melanoma influencing disease outcome and treatment decisions.
AREAS TIMELY FOR DEVELOPING RESEARCH: Education and training of patient and healthcare professionals. Role of screening, surveillance and follow-up strategies. Biology of melanoma guiding treatment decisions.