Journal of gastroenterology · 2008
Liver/spleen volume ratio as a predictor of prognosis in primary biliary cirrhosis.
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Murata Yosuke, Abe Masanori, Hiasa Yoichi, Azemoto Nobuaki, Kumagi Teru, Furukawa Shinya, Matsuura Bunzo, Michitaka Kojiro, Horiike Norio, Onji Morikazu
Аннотация
BACKGROUND: The course of primary biliary cirrhosis (PBC) is determined by clinical symptoms and histological findings. The present study examined the prognostic importance of imaging parameters in PBC.
METHODS: The volumes of the liver and spleen of patients with PBC were assessed by computed tomography (CT). The volume ratio of liver to spleen (LV/SV ratio) was evaluated and used for further analyses.
RESULTS: The prognosis was significantly poorer in PBC patients with a low, rather than high, LV/SV ratio. The Cox proportional hazard regression model showed that the serum bilirubin level and the LV/SV ratio could predict the prognosis of PBC patients. In addition, the LV/SV ratio was significantly lower in patients who developed symptoms (s-PBC) than in those who remained asymptomatic (a-PBC) during the observation period.
CONCLUSIONS: The LV/SV ratio is of prognostic importance in patients with PBC.
METHODS: The volumes of the liver and spleen of patients with PBC were assessed by computed tomography (CT). The volume ratio of liver to spleen (LV/SV ratio) was evaluated and used for further analyses.
RESULTS: The prognosis was significantly poorer in PBC patients with a low, rather than high, LV/SV ratio. The Cox proportional hazard regression model showed that the serum bilirubin level and the LV/SV ratio could predict the prognosis of PBC patients. In addition, the LV/SV ratio was significantly lower in patients who developed symptoms (s-PBC) than in those who remained asymptomatic (a-PBC) during the observation period.
CONCLUSIONS: The LV/SV ratio is of prognostic importance in patients with PBC.