Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology · 2011
Time course of hypothalamic-pituitary deficiency in adults receiving cranial radiotherapy for primary extrasellar brain tumors.
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Madaschi Sara, Fiorino Claudio, Losa Marco, Lanzi Roberto, Mazza Elena, Motta Micaela, Perna Lucia, Brioschi Elena, Scavini Marina, Reni Michele
Аннотация
BACKGROUND: No longitudinal data on hypothalamic-pituitary (HP) function are available in patients who had received cranial radiation therapy (CRT) for primary extrasellar brain tumors (PBT).
PURPOSE: To investigate the effects of CRT on HP function in adults with PBT.
PATIENTS AND METHODS: Twenty-six adults irradiated for PBT and six CRT naive controls were studied. CRT was delivered with 6 MV X-ray by a linear accelerator (2 Gy fraction schedule). Gross Tumor Volume (GTV) excluded the HP region that was contoured on the planning CT. Median dose to the HP region was 41.8 Gy (IQR: 30.7-49.8).
RESULTS: All controls maintained normal HP function. Hypopituitarism developed in 38% of CRT patients (GH deficiency 29%, ACTH 22%, TSH 14%, gonadotropin 4%, no abnormal prolactin level or diabetes insipidus). All HP failures occurred within 32 months after CRT.
CONCLUSIONS: Adults undergoing CRT for PBT are at increased risk for HP dysfunction within 3 years from CRT. Endocrine surveillance is recommended also in adults patients exposed to CRT for primary brain tumors distant from HP region.
PURPOSE: To investigate the effects of CRT on HP function in adults with PBT.
PATIENTS AND METHODS: Twenty-six adults irradiated for PBT and six CRT naive controls were studied. CRT was delivered with 6 MV X-ray by a linear accelerator (2 Gy fraction schedule). Gross Tumor Volume (GTV) excluded the HP region that was contoured on the planning CT. Median dose to the HP region was 41.8 Gy (IQR: 30.7-49.8).
RESULTS: All controls maintained normal HP function. Hypopituitarism developed in 38% of CRT patients (GH deficiency 29%, ACTH 22%, TSH 14%, gonadotropin 4%, no abnormal prolactin level or diabetes insipidus). All HP failures occurred within 32 months after CRT.
CONCLUSIONS: Adults undergoing CRT for PBT are at increased risk for HP dysfunction within 3 years from CRT. Endocrine surveillance is recommended also in adults patients exposed to CRT for primary brain tumors distant from HP region.
Предметные рубрики MeSH
Adrenocorticotropic HormoneAgedBrain NeoplasmsCase-Control StudiesChi-Square DistributionCranial IrradiationDose-Response Relationship, RadiationFemaleGonadotropinsHuman Growth HormoneHumansHypopituitarismHypothalamo-Hypophyseal SystemMaleMiddle AgedProportional Hazards ModelsRadiotherapy DosageStatistics, NonparametricThyrotropinTime FactorsTomography, X-Ray Computed