Heart & lung : the journal of critical care · 2017
Subcutaneous treprostinil was effective and tolerable in a patient with severe pulmonary hypertension associated with chronic kidney disease on hemodialysis.
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Watanabe Takanori, Abe Kohtaro, Horimoto Koshin, Hosokawa Kazuya, Ohtani Kisho, Tsutsui Hiroyuki
Аннотация
BACKGROUND: Pulmonary hypertension (PH) is a life-threatening complication in patients with chronic kidney disease on hemodialysis (CKD-HD).
OBJECTIVES: To determine whether subcutaneous infusion of treprostinil was effective and tolerable CKD-PH.
METHODS AND RESULTS: A 57-year-old man was admitted to our hospital due to presyncope and dyspnea during exercise with a history of CKD-HD. Cardiac catheterization revealed high pulmonary arterial pressure (PAP) of 53/24/32 mmHg and pulmonary vascular resistance (PVR) of 11.2 w.u. Upfront combination therapy with bosentan and sildenafil was started. However, 6-month therapy did not attenuate his symptoms, probably due to the high PAP and PVR (60/19/30 mmHg and 5.9 w.u.). We added subcutaneous treprostinil. Surprisingly, 9-month treprostinil (50 ng/kg/min) normalized hemodynamics (PAP: 25/4/13 mmHg and PVR: 1.9 w.u.). His symptoms during excise disappeared without any adverse effects.
CONCLUSION: This is the first report that subcutaneous treprostinil was very effective and tolerable in a PH patient with CKD-HD.
OBJECTIVES: To determine whether subcutaneous infusion of treprostinil was effective and tolerable CKD-PH.
METHODS AND RESULTS: A 57-year-old man was admitted to our hospital due to presyncope and dyspnea during exercise with a history of CKD-HD. Cardiac catheterization revealed high pulmonary arterial pressure (PAP) of 53/24/32 mmHg and pulmonary vascular resistance (PVR) of 11.2 w.u. Upfront combination therapy with bosentan and sildenafil was started. However, 6-month therapy did not attenuate his symptoms, probably due to the high PAP and PVR (60/19/30 mmHg and 5.9 w.u.). We added subcutaneous treprostinil. Surprisingly, 9-month treprostinil (50 ng/kg/min) normalized hemodynamics (PAP: 25/4/13 mmHg and PVR: 1.9 w.u.). His symptoms during excise disappeared without any adverse effects.
CONCLUSION: This is the first report that subcutaneous treprostinil was very effective and tolerable in a PH patient with CKD-HD.