[Directly observed treatment of latent tuberculosis infection: comparative study of two isoniazid regimens].

INTRODUCTION

To compare compliance with two isoniazid regimens in drug users with latent tuberculosis infection. METHODS.

DESIGN

clinical trial. Group 1: isoniazid 300 mg once daily (16 patients); Group 2: isoniazid 900 mg/twice weekly (21).

ENDPOINTS: compliance, toxicity and efficacy.

RESULTS

Group 1 vs. Group 2: continuation in program 81/82% (p 5 NS), compliance full doses 43.7/66.6% (p 5 0.1), median percentage of days not taking isoniazid: 1.8 (0.2-4.3) vs. 0 (0-1.7) (p 5 0.06).

CONCLUSIONS

Compliance was high in both therapeutic arms. The twice-weekly isoniazid regimen favored compliance, but differences were not significant.