Journal of clinical epidemiology · 2002
Urine testing to monitor adherence to TB preventive therapy.
СтатьяПоддержка службы здравоохранения СШАВалидационное исследованиеНазвание и аннотация: Перевод пока не подготовлен
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Perry Sharon, Hovell Melbourne F, Blumberg Elaine, Berg Jill, Vera Alicia, Sipan Carol, Kelley Norma, Moser Kathleen, Catanzaro Antonino, Friedman Larry
Аннотация
This study examined the validity of the Arkansas urine test. One hundred ninety-four adolescents submitted an unannounced urine specimen monthly (for 6 to 8 months). Duplicate specimens were blindly tested with high agreement (kappa >90%). Sensitivity and specificity were estimated. In 68% of test runs, adolescents recalled taking INH within 24 hr of specimen collection. For recall intervals of 24, 48, and 72 hr, sensitivity was 87, 85, and 83%, respectively. Females were less likely to test positive when INH was taken within the previous 24 hr (sensitivity 84 versus 92% males). Specificity was 57, 91, and 95% at 24, 48, and 72 hr, respectively. The Arkansas urine test was practical to use, and results correlated well with self-reported adherence to INH for treatment of latent tuberculosis infection (LTBI), over several months of follow-up. The test may be useful as part of an adherence-monitoring program when used in conjunction with self-reported measures.