Acta chirurgica Belgica · 2018
Myasthenia gravis appearing after thymectomy heralding recurrent thymoma.
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Beckers Paul A J, Mercelis Rudy, Heyman Stijn, Verheuen Lies, Lauwers Patrick, Hendriks Jeroen M, Van Schil Paul E
Аннотация
INTRODUCTION: Thirty to fifty percent of thymoma patients develop myasthenia gravis (MG). In 1.5-28% of cases, MG appears many years after removal of a thymoma.
PATIENTS AND METHODS: We present a case report of a 72-year-old female who presented with MG four months after total thymectomy.
RESULTS: A 72-year-old female patient presents with MG four months after total thymectomy. Imaging revealed a PET-positive nodule anterior to the superior vena cava. By median sternotomy, the nodule was removed at our hospital. Pathology confirmed a recurrent B2/B3 thymoma with R0 resection. No adjuvant therapy was given. Large population studies show the appearance of new-onset MG associated with recurrent thymoma in 3% of cases.
CONCLUSIONS: New-onset MG postthymectomy heralds recurrent disease in 3% of cases. Thorough screening is needed in such patients.
PATIENTS AND METHODS: We present a case report of a 72-year-old female who presented with MG four months after total thymectomy.
RESULTS: A 72-year-old female patient presents with MG four months after total thymectomy. Imaging revealed a PET-positive nodule anterior to the superior vena cava. By median sternotomy, the nodule was removed at our hospital. Pathology confirmed a recurrent B2/B3 thymoma with R0 resection. No adjuvant therapy was given. Large population studies show the appearance of new-onset MG associated with recurrent thymoma in 3% of cases.
CONCLUSIONS: New-onset MG postthymectomy heralds recurrent disease in 3% of cases. Thorough screening is needed in such patients.