History of thyroid disease and survival of ovarian cancer patients: results from the Ovarian Cancer Association Consortium, a brief report.
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Minlikeeva Albina N, Freudenheim Jo L, Cannioto Rikki A, Eng Kevin H, Szender J Brian, Mayor Paul, Etter John L, Cramer Daniel W, Diergaarde Brenda, Doherty Jennifer A, Dörk Thilo, Edwards Robert, deFazio Anna, Friel Grace, Goodman Marc T, Hillemanns Peter, Høgdall Estrid, Jensen Allan, Jordan Susan J, Karlan Beth Y, Kjær Susanne K, Klapdor Rüdiger, Matsuo Keitaro, Mizuno Mika, Nagle Christina M, Odunsi Kunle, Paddock Lisa, Rossing Mary Anne, Schildkraut Joellen M, Schmalfeldt Barbara, Segal Brahm H, Starbuck Kristen, Terry Kathryn L, Webb Penelope M, Zsiros Emese, Ness Roberta B, Modugno Francesmary, Bandera Elisa V, Chang-Claude Jenny, Moysich Kirsten B
Аннотация
METHODS: We pooled data from 11 studies from the Ovarian Cancer Association Consortium. Using multivariate Cox proportional hazards models, we estimated associations between hyper- and hypothyroidism and medications prescribed for these conditions with 5-year all-cause survival among women diagnosed with invasive ovarian cancer.
RESULTS: Overall, there was a nonsignificant association with history of hyperthyroidism (n=160 cases) and mortality (HR=1.22; 95% CI=0.97-1.53). Furthermore, diagnosis of hyperthyroidism within the 5 years before ovarian cancer diagnosis was associated with an increased risk of death (HR=1.94; 95% CI=1.19-3.18). A more modest association was observed with history of hypothyroidism (n=624 cases) and mortality (HR=1.16; 95% CI=1.03-1.31). Neither duration of hypothyroidism nor use of thyroid medications was associated with survival.
CONCLUSIONS: In this large study of women with ovarian cancer, we found that recent history of hyperthyroidism and overall history of hypothyroidism were associated with worse 5-year survival.