Updated Clinical Evidence for Effective Cardiac Resynchronization Therapy in Congestive Heart Failure and Timing of Implant.

Investigative works of the past 20 years have compiled extensive data on the effectiveness and implications of cardiac resynchronization therapy (CRT) in patients with heart failure. Since then, CRT has become a well-accepted and widely adapted adjunctive therapy for patients with heart failure with ventricular dyssynchrony. This overview discusses the updated knowledge on the benefits afforded with CRT and reviews the major clinical trials that have established CRT at its current practice. Based on the data, the indications of CRT and the timing of appropriate implant of CRT devices with respect to heart failure status will be presented.