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European urology · 2026

Diagnosis and Staging of Patients with Prostate Cancer: Report from the 2025 Advanced Prostate Cancer Consensus Conference (APCCC) Diagnostics.

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Fanti Stefano, Turco Fabio, Tombal Bertrand, Walz Jochen, Hofman Michael S, Hadaschik Boris, Emmett Louise, Tilki Derya, Pecoraro Giovanna, Salfi Giuseppe, Attard Gerhardt, Beltran Himisha, Bjartell Anders, Briganti Alberto, Burger Irene A, Castro Elena, Cerci Juliano J, Chiti Arturo, Cooperberg Matthew, Fizazi Karim, Fossati Nicola, Gafita Andrei, Gallina Andrea, Goffin Karolien, Horvath Lisa G, Hugosson Jonas, Iagaru Andrei, James Nicholas D, Kasivisvanathan Veeru, Koh Dow-Mu, Kristiansen Glen, Kumar Rakesh, Lecouvet Frederic, Loeb Stacy, McKay Rana R, Morris Michael J, Murphy Declan G, Murthy Vedang, Naoun Natacha, Oprea-Lager Daniela E, Ost Piet, O'Sullivan Joe, Padhani Anwar R, Palapattu Ganesh, Paone Gaetano, Petralia Giuseppe, Roobol Monique J, Sartor Oliver A, Sathekge Mike, Schuster David M, Seibert Tyler M, Spratt Daniel E, Tempany Clare, Tunariu Nina, Vargas H Alberto, Vogl Ursula M, Wyatt Alexander W, Zilli Thomas, Lin Hui-Ming, Omlin Aurelius, Gillessen Silke, Herrmann Ken

Аннотация

BACKGROUND: For over a decade the Advanced Prostate Cancer Consensus Conference (APCCC) covers a variety of topics that greatly impact daily practice. In 2025, a dedicated event was organised to discuss key questions in clinical management of patients with prostate cancer (PC) related to diagnostic tools (APCCC Diagnostics). Here we present the voting results of the APCCC Diagnostics questions. OBJECTIVE; DESIGN, SETTING, AND PARTECIPANTS: APCCC Diagnostics 2025 is a pilot project. The scientific committee for APCCC Diagnostics 2025 developed 88 multiple-choice consensus questions on six different topics. Prior to the conference, the panel members (''panellists'') voted on these questions via a web-based survey. Consensus was defined as ≥75% agreement, with strong consensus defined as ≥90% agreement.

OUTCOMES MEASUREMENTS AND STATISTICAL ANALYSIS: Consensus was only reached on 17 of 88 questions (19%), of which six (7%) received a strong consensus. Specifically, consensus was reached for two of 17 questions (14%) in "how to diagnose PC"; seven of 16 (44%) in "how to stage PC"; three of 14 (21%) in "Biochemical Recurrence Scenario"; two of 11 (18%) in "metastatic disease: what to do?"; zero of 18 (0%) in "monitoring metastatic PC"; and three of 12 (25%) in "radioligand therapy and imaging."

CONCLUSIONS: The voting results and their discussion may assist physicians in navigating controversial areas of clinical management related to diagnosis, staging, and restaging in the different clinical settings for PC, particularly where high-level evidence is scarce or conflicting. The findings can also help funders and policymakers in prioritising areas for future research.

ИП Урсолов Владлен Сергеевич

ИНН 500118482352 · ОГРНИП 314500117700049

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