His Bundle Pacing for Cardiac Resynchronization.

Cardiac resynchronization therapy with left ventricular coronary sinus or epicardial pacing is an established therapy for patients with systolic heart failure and intraventricular conduction system delay, particularly left bundle branch block. Despite large-scale randomized trials demonstrating the efficacy of this therapy, clinical and echocardiographic nonresponse rates remain as high as up to 40%. His bundle pacing (HBP) has reemerged as a means to provide physiologic resynchronization in patients with bundle branch block by correcting QRS by direct capture of the His-Purkinje system. This critical appraisal reviews early clinical data, evaluates possible mechanism, and identifies areas for future investigation for HBP in resynchronization.