Zhurnal mikrobiologii, epidemiologii i immunobiologii · 2015
[Signs of microbial sensibilization in patients with various cardiovascular diseases].
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Karpunina N S, Bakhmet'ev B A, Zaikina M V
Аннотация
AIM: Analysis of intensity of non-specific (level of sera cytokines) and specific (titers of antibodies against Chlamydophila pneumoniae) factors of humoral immunity in patients with arterial hypertension and various forms of ischemic heart diseases.
MATERIALS AND METHODS: 282 individuals were the object of examination--157 (55.7%) males. 8 groups were formed, comparable by age: 1 - 32 individuals with exertional angina pectoris of the III functional class; 2 - 20 individuals with healing Q-positive myocardial infarction (MI); 3 - 15 individuals with Q-negative healing MI; 4 - 15 individuals with unstable angina pectoris; 5 - 40 individuals with persisting atrium fibrillation; 6 - 35 individuals with clinically significant chronic heart failure; 7 - 92 patients with hypertension of the II stage; 33 conditionally healthy composed the control group. Class A and G immunoglobulins against C. pneumoniae, IL-1β, -6, -17, TNFα content in blood were determined.
RESULTS: The proportion of seropositive individuals in groups with IgG and IgA titer characteristics was determined. Data on the level of cytokines, taking into the account seropositivity, and titer increase are presented. Correlations between hemostasis system were established, that demonstrate increase of thrombophilia in the presence of persistent infection, mediated via induction of cytokine production. Significant differences by instrumental parameters depending on seropositivity were not obtained.
CONCLUSION: Contribution of microbial sensibilization and latent inflammation in the development and destabilization of atherogenesis-associated diseases seems evident.
MATERIALS AND METHODS: 282 individuals were the object of examination--157 (55.7%) males. 8 groups were formed, comparable by age: 1 - 32 individuals with exertional angina pectoris of the III functional class; 2 - 20 individuals with healing Q-positive myocardial infarction (MI); 3 - 15 individuals with Q-negative healing MI; 4 - 15 individuals with unstable angina pectoris; 5 - 40 individuals with persisting atrium fibrillation; 6 - 35 individuals with clinically significant chronic heart failure; 7 - 92 patients with hypertension of the II stage; 33 conditionally healthy composed the control group. Class A and G immunoglobulins against C. pneumoniae, IL-1β, -6, -17, TNFα content in blood were determined.
RESULTS: The proportion of seropositive individuals in groups with IgG and IgA titer characteristics was determined. Data on the level of cytokines, taking into the account seropositivity, and titer increase are presented. Correlations between hemostasis system were established, that demonstrate increase of thrombophilia in the presence of persistent infection, mediated via induction of cytokine production. Significant differences by instrumental parameters depending on seropositivity were not obtained.
CONCLUSION: Contribution of microbial sensibilization and latent inflammation in the development and destabilization of atherogenesis-associated diseases seems evident.