Dental traumatology : official publication of International Association for Dental Traumatology · 2005
Histological comparison of alendronate, calcium hydroxide and formocresol in amputated rat molar.
Сравнительное исследованиеСтатьяНазвание и аннотация: Перевод пока не подготовлен
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Cengiz S Burcak, Batirbaygil Yildiz, Onur Mehmet Ali, Atilla Pergin, Asan Esin, Altay Nil, Cehreli Zafer C
Аннотация
The purpose of this study was to evaluate the potential of alendronate sodium (ALN), a biphosohonate to stimulate hard tissue formation in pulpotomized (amputated) rat molars. Two commonly used pulpotomy materials, calcium hydroxide (CH) and formocresol (FC) were utilized for comparisons. Histological evaluations were performed by observers blinded to treatment allocation on days 7, 15, 30 and 60, followed by statistical analysis of selected histological criteria. In all evaluation periods, hard tissue deposition was evident along the radicular dentin in ALN and CH groups. In days 30 and 60, the latter two groups showed no differences in inflammatory cell response and hard tissue deposition scores (P > 0.05). ALN appears to be capable of maintaining pulpal vitality, while promoting hard tissue formation, similar to CH.