Scandinavian cardiovascular journal : SCJ · 2014
Usefulness of the platelet-to-lymphocyte ratio in predicting bare-metal stent restenosis.
Оценочное исследованиеСтатьяНазвание и аннотация: Перевод пока не подготовлен
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Yılmaz Samet, Sen Fatıh, Ünal Sefa, Yayla Cağri, Özeke Özcan, Aras Dursun, Topaloglu Serkan, Aydogdu Sınan
Аннотация
OBJECTIVES: Platelet-to-lymphocyte ratio (PLR) provides a simple method for assessment of inflammatory status. The aim of the present study was to investigate the predictive value of preprocedural PLR on development of in-stent restenosis in patients undergoing bare-metal stent (BMS) implantation.
DESIGN: Six hundred and seventy-five consecutive patients (mean age: 60.6 ± 8.3, 66% men) who had undergone successful BMS implantation and additional coronary angiography for stable or unstable angina pectoris were analyzed. Mean period between 2 coronary angiographies was 14.3 ± 3.4 months.
RESULTS: Patients were divided into tertiles based on preprocedural PLR. Restenosis occurred in 58 patients (26%) in the lowest tertile, in 82 (36%) in the middle tertile, and in 115 (51%) in the highest tertile (p < 0.001). Serum C-reactive protein levels were also significantly higher in patients in tertile 3 than in those in tertiles 1 and 2 (p < 0.001). Smoking, diabetes mellitus, high-density lipoprotein, stent length, preprocedural PLR, and C-reactive protein levels emerged as independent predictors of in-stent restenosis. In receiver-operating characteristics curve analysis, PLR >122 had 81% sensitivity and 72% specificity in predicting in-stent restenosis.
CONCLUSIONS: High preprocedural PLR is a powerful and independent predictor of BMS restenosis in patients with stable and unstable angina pectoris.
DESIGN: Six hundred and seventy-five consecutive patients (mean age: 60.6 ± 8.3, 66% men) who had undergone successful BMS implantation and additional coronary angiography for stable or unstable angina pectoris were analyzed. Mean period between 2 coronary angiographies was 14.3 ± 3.4 months.
RESULTS: Patients were divided into tertiles based on preprocedural PLR. Restenosis occurred in 58 patients (26%) in the lowest tertile, in 82 (36%) in the middle tertile, and in 115 (51%) in the highest tertile (p < 0.001). Serum C-reactive protein levels were also significantly higher in patients in tertile 3 than in those in tertiles 1 and 2 (p < 0.001). Smoking, diabetes mellitus, high-density lipoprotein, stent length, preprocedural PLR, and C-reactive protein levels emerged as independent predictors of in-stent restenosis. In receiver-operating characteristics curve analysis, PLR >122 had 81% sensitivity and 72% specificity in predicting in-stent restenosis.
CONCLUSIONS: High preprocedural PLR is a powerful and independent predictor of BMS restenosis in patients with stable and unstable angina pectoris.
Предметные рубрики MeSH
AgedAngina, StableAngina, UnstableArea Under CurveCoronary AngiographyCoronary RestenosisFemaleHumansLymphocyte CountMaleMetalsMiddle AgedPercutaneous Coronary InterventionPlatelet CountPredictive Value of TestsProsthesis DesignROC CurveRetrospective StudiesRisk AssessmentRisk FactorsStentsTreatment Outcome