Zhonghua yi xue za zhi · 2014
[Myocardial protective effect of Danhong Injection evaluated by velocity vector imaging in patients undergoing percutaneous coronary intervention].
СтатьяРандомизированное исследованиеНазвание и аннотация: Перевод пока не подготовлен
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Dong Jing, Chen Yundai, Zhi Guang, Liu Hongxu, Wang Jing, Tian Feng, Zhou Ying, Chen Jinsong
Аннотация
OBJECTIVE: To observe the myocardial protective effect of Danhong Injection evaluated by velocity vector imaging (VVI) in patients with unstable angina pectoris after percutaneous coronary intervention (PCI) and elucidate its possible mechanism.
METHODS: A total of 120 patients were randomized into Danhong (DG, n = 60) or control (CG, n = 60) groups. The patients in CG group received regular medication according to the guidelines while those in DG group regular medication plus Danhong Injection before and after PCI. During PCI, 40 ml Danhong Injection was administrated intravenously. The levels of CK-MB and cTnT were tested before and 24 hours after PCI. And VVI was performed before and 24 hours after PCI.
RESULTS: After treatment with Danhong injection, the serum level of MB isoenzyme of creatine kinase (CK-MB) and cardiac troponin T (cTnT) in DG were lower than those in CG (18.19 ± 10.23 vs 25.12 ± 11.91,0.079 ± 0.007 vs 0.132 ± 0.011, P < 0.05). Meanwhile, strain and strain rate of interventricular septum apex, anterior apex, inferior basement and inferior middle segment were better in DG than those in CG (26.01 ± 7.94 vs 23.25 ± 6.68, 20.91 ± 7.55 vs 18.79 ± 8.45, 18.10 ± 7.31 vs 16.89 ± 6.05, 21.16 ± 6.42 vs 18.37 ± 6.54, P < 0.05; 1.93 ± 0.79 vs 1.69 ± 0.63, 1.86 ± 0.72 vs 1.63 ± 0.68, 1.51 ± 0.80 vs 1.25 ± 0.54, 1.50 ± 0.45 vs 1.33 ± 0.32, P < 0.05 respectively).
CONCLUSION: Peri-procedual Danhong injection can ameliorate myocardial injury and improve segmental systolic function.
METHODS: A total of 120 patients were randomized into Danhong (DG, n = 60) or control (CG, n = 60) groups. The patients in CG group received regular medication according to the guidelines while those in DG group regular medication plus Danhong Injection before and after PCI. During PCI, 40 ml Danhong Injection was administrated intravenously. The levels of CK-MB and cTnT were tested before and 24 hours after PCI. And VVI was performed before and 24 hours after PCI.
RESULTS: After treatment with Danhong injection, the serum level of MB isoenzyme of creatine kinase (CK-MB) and cardiac troponin T (cTnT) in DG were lower than those in CG (18.19 ± 10.23 vs 25.12 ± 11.91,0.079 ± 0.007 vs 0.132 ± 0.011, P < 0.05). Meanwhile, strain and strain rate of interventricular septum apex, anterior apex, inferior basement and inferior middle segment were better in DG than those in CG (26.01 ± 7.94 vs 23.25 ± 6.68, 20.91 ± 7.55 vs 18.79 ± 8.45, 18.10 ± 7.31 vs 16.89 ± 6.05, 21.16 ± 6.42 vs 18.37 ± 6.54, P < 0.05; 1.93 ± 0.79 vs 1.69 ± 0.63, 1.86 ± 0.72 vs 1.63 ± 0.68, 1.51 ± 0.80 vs 1.25 ± 0.54, 1.50 ± 0.45 vs 1.33 ± 0.32, P < 0.05 respectively).
CONCLUSION: Peri-procedual Danhong injection can ameliorate myocardial injury and improve segmental systolic function.