[Neutrophil gelatinase-associated lipocain as a predictor of acute renal lesion in patients with acute coronary syndrome].

To estimate the possibility of using neutrophil gelatinase-associated lipocain (NGAL) as a predictor of acute renal lesion (ARL) in patients with acute coronary syndrome (ACS). Only those patients were included in whom coronarography was found to be impracticable which allowed to exclude the development of contrast-induced ARL. A total of 122 patients with ACS (69 men and 53 women, mean age 64 +/- 11 yr) were available for examination. 18 (15%) patients had acute myocardial infarction without ST elevation, 73 (60%) presented with unstable angina. ARL was diagnosed and classified following KDIGO recommendations (2012). Serum creatinine level was determined at admission. (Urine NGAL level was measured by an immunoenzyme assay. ARL was diagnosed in 27 (22%) patients (stage 1 in 26%. stage 2 in 1%). NGAL level above 82 ng/ml was a highly specific (99%) predictor of ARL in patients with ACS, but its sensitivity did not exceed 20%. It is concluded that urinary NGAL is a moderate predictor of ARL in patients with ACS whose specificity increases with increasing urinary level.