Assessment of Oxidative Stress and Neuronal Damage Indicators After Parathyroidectomy in Patients With Primary Hyperparathyroidism.

BACKGROUND

Primary hyperparathyroidism (PHPT) is associated with neurological damage, which tends to improve after parathyroidectomy (PTX). Oxidative stress might play a role in these pathological changes. This study aimed to investigate oxidative stress and neuronal damage markers following PTX in patients with PHPT.

METHODS

The study involved 36 patients with PHPT who underwent surgical treatment. Markers for oxidative stress, including serum total antioxidant status (TAS), total oxidative status (TOS), oxidative stress index (OSI), 7-ketocholesterol (7-KC) and cholestan-3β,5α,6β-triol (C-triol) as oxysterols and 8-iso-prostaglandin F2α (8-iso-PGF2α), were measured, along with neurofilament light chain (NfL) as a marker for neuronal damage. These markers were assessed before and six months after PTX.

RESULTS

Following PTX, a significant reduction in OSI was observed (p = 0.020), while TAS, TOS, oxysterol, 8-iso-PGF2α, and NfL levels remained unchanged. There was no correlation between baseline serum calcium and parathyroid hormone levels with baseline oxidative stress markers or NfL levels. However, baseline TAS levels showed a correlation with baseline NfL levels (r = -0.370), which was not present after surgery.

CONCLUSIONS

These findings suggest oxidative stress is elevated in patients with PHPT and may contribute to neurological complications. Post surgery, oxidative stress levels decrease, as reflected by a significant reduction in OSI; whether this translates into better central nervous system outcomes warrants confirmation in future studies.