Comparison of the PCA titer and aerosol microshock time in guinea pigs made sensitive to ragweed.

Guinea pigs were sensitized either by intranasal dusting with ragweed (RW) pollen or by intranasal instillation of RW extract and subsequently challenged with a RW extract aerosol. It was relatively easy to determine the microshock time for animals which responded between 0 and 10 minutes. Sera from these sensitive guinea pigs were tittered by passive cutaneous anaphylaxis tests. Data from these two assays showed a semilogarithmic relationship with a correlation coefficient of -0.934.