[Possibilities and limitations of desensitization].

Since the introduction of hyposensitization more than 60 years ago as a therapeutic principle in allergic diseases the method has brought good success especially in atopic sensitizations. Pollen, domestic dust and insect allergy are generally accepted indications. The chances in these types of allergy are rather good, especially when the following points have been taken into consideration: A correct indication by subtile investigation, the best choice of allergens and optinal intervalls of applications, the sufficient duration of treatment, a reasonable high final dosis and avoidance of contraindications. Improvements in the success of this therapy as well as facilitation of the practical performance (e.g. by introduction of new allergen preparations) can be expected in the next future by intensified basic immunologic research inclose connexion with clinical practice.