Pharmacology of new 7-gamma-piperazino-beta-hydroxypropyl theophline derivatives. Part II. The effect on course and dynamics of delayed contact allergy produced with 2,4-dinitrochlorobenzene (DNCB) in guinea pigs.

The action of three new 7-gamma-piperazion-beta-hydroxypropyl theophylline derivatives on the course and dynamics of development of skin reaction in delayed hypersensitivity produced by a potent sensitizing agent (DNBC) was studied. The preventive action, particularly of compound R6, against exudate and edema of the sites of depot of the antigen in the guinea pig is similar to the effect produced by classical antihistaminics, as mepyramine mepyramine or tavegyl. It has been found histopathologically that compound R6 does not change the localization and proliferation of mononuclear perivascular cells typical for delayed hypersensitivity.