Local erythema multiforme-like drug reaction following intravenous mitomycin C and 5-fluorouracil.

A localized skin reaction occurred within 4 weeks following IV administration of mitomycin C and 5-FU. Erythematous papules appeared proximal to the forearm site used for drug administration that histologically resembled an erythema multiforme-like drug reaction. A localized hypersensitivity reaction to mitomycin C is suspected.