Journal of pediatric gastroenterology and nutrition · 2012
Are immunoglobulin A anti-gliadin antibodies helpful in diagnosing coeliac disease in children younger than 2 years?
Оценочное исследованиеСтатьяНазвание и аннотация: Перевод пока не подготовлен
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Foucher Barbara, Johanet Catherine, Jégo-Desplat Sophie, Sanmarco Marielle, Dubucquoi Sylvain, Fily-Nalewajk Sandrine, Olsson Nils-Olivier, Lakomy Daniela, Escande Andrée, Chrétien Pascale, Fortenfant Françoise, Chevailler Alain, André Chantal, Goetz Joëlle, Humbel René-Louis, Monier Jean-Claude, Sibilia Jean, Taillefer Marie-France, Abreu Isabelle, Fabien Nicole
Аннотация
The usefulness of immumoglobulin (Ig) A antibodies to gliadin (AGA-IgA) in addition to IgA anti-endomysium and tissue transglutaminase antibodies was evaluated in 4122 children younger than 2 years with a suspicion of coeliac disease (CD). Eight percent (312/4122) displayed IgA anti-endomysium and/or IgA anti-tissue transglutaminase, whereas 2.1% (85/4122) displayed only AGA-IgA. Clinical data were obtained for 62 of 85 children with isolated AGA-IgA, and 33 children underwent a duodenal biopsy. Histologically proven CD was established for 5 patients, whereas 57 children were diagnosed to experience other diseases. The systematic detection of AGA-IgA using native gliadin conferred no additional diagnostic benefit for the diagnosis of CD in children younger than 2 years of age, except for rare cases.