Design of MOSAAIC (Multi-Ethnic Observational Study in American Asian and Pacific Islander Communities).
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Ahn Jiyoung, Ahsan Habibul, Anderson Garnet L, Aschebrook-Kilfoy Briseis, Beery Danny, Carrick William, Celedón Juan C, Chan K C Gary, Chen Yu, Ðoàn Lan N, Fang Carolyn Y, Floyd James S, Hayes Richard B, Henderson Victor, Hong Yuling, Hsing Ann W, Hsu Li, Hu Frank B, Jin Jingyu Linna, John Esther M, Kanaya Alka M, Kaplan Robert C, Kibriya Muhammad G, Kim Karen, Kushida Clete, Lampe Johanna W, Li ShangJu, Lu Ying, Ma Grace X, Mau Marjorie K L M, Maunakea Alika K, Mendoza Jason A, Neuhouser Marian L, Newman Jonathan D, Odden Michelle C, Palaniappan Latha, Park S Lani, Randal Fornessa, Rhew Isaac C, Santos Stephanie, Soliman Elsayed Z, Thyagarajan Bharat, Hsin-Chun Tsai Jenny, VoPham Trang, Wang Paul, Wion Emily, Yan Ye, Yi Stella S, Zhu Lin, MOSAAIC Investigators
Аннотация
OBJECTIVES: The MOSAAIC (Multi-ethnic Observational Study in American Asian and Pacific Islander Communities) is a cohort study designed to improve understanding of disparities in cardiovascular disease and other health conditions affecting AsA and NHPI groups.
METHODS: Through broad eligibility criteria and outreach tailored to each study community, MOSAAIC will include 11,500 adults aged 18+ years living in 5 field center regions: New York, Philadelphia, Chicago, San Francisco Bay Area, and Honolulu. The protocol specifies sample-size targets to allow valid comparisons among persons having personal or family origins in 4 geographically defined regions, including East Asia (the largest groups being Chinese and Korean), South Asia (Indian), Southeast Asia (Vietnamese and Filipino) and Oceania (NHPI). Measurements to be obtained at an in-person examination include clinical laboratory tests, medical history, medication use, spirometry, cognitive and physical function, anthropometry, and electrocardiogram. Surveys in multiple languages to assess medical, behavioral, lifestyle, social and environmental influences on health were developed by a multistep process to ensure equivalency between translations and cultural appropriateness. Biospecimens are stored for future studies. Long-term follow-up will be conducted to ascertain and adjudicate major health events including myocardial infarction, stroke, heart failure, and mortality.
CONCLUSIONS: The National Institutes of Health established MOSAAIC as a resource for wide-ranging epidemiologic investigation of factors related to cardiometabolic, pulmonary, or mental health in persons of diverse AsA and NHPI background.