Acta oto-laryngologica · 2026
The effect of tumor budding index on clinical parameters in early-stage oral cavity cancers.
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Toprak Felat, Arslan Ayça, Büyük Bayram Barış, Benzer Emine, Bozdoğan Nazan
Аннотация
BACKGROUND: Tumor budding is an established prognostic marker in colorectal cancer however, it is not routinely incorporated into risk assessment in oral cavity squamous cell carcinoma.
AIMS: To evaluate the impact of tumor budding on survival outcomes and lymph node metastasis in patients with oral cavity cancer undergoing surgical treatment.
MATERIAL AND METHODS: Between January 1, 2010 and January 1, 2021, 87 patients diagnosed with oral cavity cancer and who underwent surgery at our clinic were included in the study. Clinically T1-2 was observed in 60 patients (69%), T3-4 in 27 patients (31%), and neck dissection was not performed in 8 patients with T1N0M0 due to comorbidities.
RESULTS: The most common site was the tongue in 61 cases (70.1%), followed by the buccal mucosa in 15 cases (17.2%). The median follow-up period was 46.5 months (0.3-160.9). Tumor budding was identified as an independent predictor of overall survival, disease-free survival, and lymph node metastasis in early-stage oral cavity squamous cell carcinoma.
CONCLUSION: The presence of budding was associated with an increased risk of lymph node metastasis and shorter overall and disease-free survival.
SIGNIFICANCE: Routine assessment of tumor budding may contribute to postoperative risk classification and follow-up planning, beyond staging parameters.
AIMS: To evaluate the impact of tumor budding on survival outcomes and lymph node metastasis in patients with oral cavity cancer undergoing surgical treatment.
MATERIAL AND METHODS: Between January 1, 2010 and January 1, 2021, 87 patients diagnosed with oral cavity cancer and who underwent surgery at our clinic were included in the study. Clinically T1-2 was observed in 60 patients (69%), T3-4 in 27 patients (31%), and neck dissection was not performed in 8 patients with T1N0M0 due to comorbidities.
RESULTS: The most common site was the tongue in 61 cases (70.1%), followed by the buccal mucosa in 15 cases (17.2%). The median follow-up period was 46.5 months (0.3-160.9). Tumor budding was identified as an independent predictor of overall survival, disease-free survival, and lymph node metastasis in early-stage oral cavity squamous cell carcinoma.
CONCLUSION: The presence of budding was associated with an increased risk of lymph node metastasis and shorter overall and disease-free survival.
SIGNIFICANCE: Routine assessment of tumor budding may contribute to postoperative risk classification and follow-up planning, beyond staging parameters.