American journal of obstetrics and gynecology · 2010
Uterine artery embolization vs hysterectomy in the treatment of symptomatic uterine fibroids: 5-year outcome from the randomized EMMY trial.
Сравнительное исследованиеСтатьяМногоцентровое исследованиеРандомизированное исследованиеПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
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van der Kooij Sanne M, Hehenkamp Wouter J K, Volkers Nicole A, Birnie Erwin, Ankum Willem M, Reekers Jim A
Аннотация
OBJECTIVE: The purpose of this study was to compare clinical outcome and health related quality of life (HRQOL) 5 years after uterine artery embolization (UAE) or hysterectomy in the treatment of menorrhagia caused by uterine fibroids.
STUDY DESIGN: Patients with symptomatic uterine fibroids who were eligible for hysterectomy were assigned randomly 1:1 to hysterectomy or UAE. Endpoints after 5 years were reintervention rates, menorrhagia, and HRQOL measures that were assessed by validated questionnaires.
RESULTS: Patients were assigned randomly to UAE (n = 88) or hysterectomy (n = 89). Five years after treatment 23 of 81 UAE patients (28.4%) had undergone a hysterectomy because of insufficient improvement of complaints (24.7% after successful UAE). HRQOL measures improved significantly and remained stable until the 5-year follow-up evaluation, with no differences between the groups. UAE had a positive effect both on urinary and defecation function.
CONCLUSION: UAE is a well-established alternative to hysterectomy about which patients should be counseled.
STUDY DESIGN: Patients with symptomatic uterine fibroids who were eligible for hysterectomy were assigned randomly 1:1 to hysterectomy or UAE. Endpoints after 5 years were reintervention rates, menorrhagia, and HRQOL measures that were assessed by validated questionnaires.
RESULTS: Patients were assigned randomly to UAE (n = 88) or hysterectomy (n = 89). Five years after treatment 23 of 81 UAE patients (28.4%) had undergone a hysterectomy because of insufficient improvement of complaints (24.7% after successful UAE). HRQOL measures improved significantly and remained stable until the 5-year follow-up evaluation, with no differences between the groups. UAE had a positive effect both on urinary and defecation function.
CONCLUSION: UAE is a well-established alternative to hysterectomy about which patients should be counseled.
Предметные рубрики MeSH
AdultFemaleFollow-Up StudiesHumansHysterectomyHysterectomy, VaginalKaplan-Meier EstimateLeiomyomaMiddle AgedNeoplasm StagingPain MeasurementPostoperative PainPatient SatisfactionPostoperative ComplicationsProspective StudiesQuality of LifeRisk AssessmentStatistics, NonparametricTime FactorsTreatment OutcomeUterine Artery EmbolizationUterine Neoplasms