BMC endocrine disorders · 2015
Subclinical and clinical hypothyroidism and non-alcoholic fatty liver disease: a cross-sectional study of a random population sample aged 18 to 65 years.
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Ludwig Ulla, Holzner Daniela, Denzer Christian, Greinert Artur, Haenle Mark Martin, Oeztuerk Suemeyra, Koenig Wolfgang, Boehm Bernhard Otto, Mason Richard Andrew, Kratzer Wolfgang, Graeter Tilmann, EMIL-Study
Аннотация
BACKGROUND: Non-alcoholic fatty liver disease (NAFLD) is one of the most common disorders of the liver worldwide. Recently, a correlation between thyroid dysfunction and NAFLD has been discussed. Objective of the present study was to investigate the association between thyroid dysfunction and hepatic steatosis.
METHODS: Data from 2,445 subjects (51.7% females) aged 18 to 65 years participating in a population-based cross-sectional study were assessed based on a standardized questionnaire and documentation of physical, biochemical and ultrasonographic findings. After application of exclusion criteria, a total of 1,276 subjects were included in the study collective. The influence of potential factors on the development of hepatic steatosis was assessed using multivariate logistic regression.
RESULTS: The prevalence of hepatic steatosis in the study collective was 27.4% (n = 349). The serum thyroxin (TT4) concentration in subjects with hepatic steatosis was reduced (p =0.0004). Adjusting for age, or BMI, there was an increased prevalence of hepatic steatosis in subjects with reduced TT4 concentrations (p = 0.0143; p = < .0001).
CONCLUSIONS: The findings of the present study confirm an association between both subclinical and clinical hypothyroidism and hepatic steatosis.
METHODS: Data from 2,445 subjects (51.7% females) aged 18 to 65 years participating in a population-based cross-sectional study were assessed based on a standardized questionnaire and documentation of physical, biochemical and ultrasonographic findings. After application of exclusion criteria, a total of 1,276 subjects were included in the study collective. The influence of potential factors on the development of hepatic steatosis was assessed using multivariate logistic regression.
RESULTS: The prevalence of hepatic steatosis in the study collective was 27.4% (n = 349). The serum thyroxin (TT4) concentration in subjects with hepatic steatosis was reduced (p =0.0004). Adjusting for age, or BMI, there was an increased prevalence of hepatic steatosis in subjects with reduced TT4 concentrations (p = 0.0143; p = < .0001).
CONCLUSIONS: The findings of the present study confirm an association between both subclinical and clinical hypothyroidism and hepatic steatosis.
Предметные рубрики MeSH
AdolescentAdultAge FactorsAgedAlanine TransaminaseAspartate AminotransferasesCross-Sectional StudiesDiabetes MellitusFemaleGermanyHumansHypertensionHypothyroidismLogistic ModelsMaleMetabolic SyndromeMiddle AgedMultivariate AnalysisNon-alcoholic Fatty Liver DiseaseOverweightPrevalenceSeverity of Illness IndexThyrotropinThyroxineTriiodothyronineUltrasonographyWaist-Hip RatioYoung Adult