Carotid intima-media thickness progression and risk of vascular events in people with diabetes: results from the PROG-IMT collaboration.
Обработка статьи · этапы, ошибки и управление
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Lorenz Matthias W, Price Jackie F, Robertson Christine, Bots Michiel L, Polak Joseph F, Poppert Holger, Kavousi Maryam, Dörr Marcus, Stensland Eva, Ducimetiere Pierre, Ronkainen Kimmo, Kiechl Stefan, Sitzer Matthias, Rundek Tatjana, Lind Lars, Liu Jing, Bergström Göran, Grigore Liliana, Bokemark Lena, Friera Alfonsa, Yanez David, Bickel Horst, Ikram M Arfan, Völzke Henry, Johnsen Stein Harald, Empana Jean Philippe, Tuomainen Tomi-Pekka, Willeit Peter, Steinmetz Helmuth, Desvarieux Moise, Xie Wuxiang, Schmidt Caroline, Norata Giuseppe D, Suarez Carmen, Sander Dirk, Hofman Albert, Schminke Ulf, Mathiesen Ellisiv, Plichart Matthieu, Kauhanen Jussi, Willeit Johann, Sacco Ralph L, McLachlan Stela, Zhao Dong, Fagerberg Björn, Catapano Alberico L, Gabriel Rafael, Franco Oscar H, Bülbül Alpaslan, Scheckenbach Frank, Pflug Anja, Gao Lu, Thompson Simon G
Аннотация
RESEARCH DESIGN AND METHODS: In a comprehensive meta-analysis of individual participant data, we collated data from 3,902 adults (age 33-92 years) with type 2 diabetes from 21 population-based cohorts. We calculated the hazard ratio (HR) per standard deviation (SD) difference in mean common carotid artery intima-media thickness (CCA-IMT) or in CCA-IMT progression, both calculated from two examinations on average 3.6 years apart, for each cohort, and combined the estimates with random-effects meta-analysis.
RESULTS: Average mean CCA-IMT ranged from 0.72 to 0.97 mm across cohorts in people with diabetes. The HR of CVD events was 1.22 (95% CI 1.12-1.33) per SD difference in mean CCA-IMT, after adjustment for age, sex, and cardiometabolic risk factors. Average mean CCA-IMT progression in people with diabetes ranged between -0.09 and 0.04 mm/year. The HR per SD difference in mean CCA-IMT progression was 0.99 (0.91-1.08).
CONCLUSIONS: Despite reproducing the association between CIMT level and vascular risk in subjects with diabetes, we did not find an association between CIMT change and vascular risk. These results do not support the use of CIMT progression as a surrogate end point in clinical trials in people with diabetes.