[Proliferating cell nuclear antigen expression in recurrent aphthous ulcer and its significance].

OBJECTIVE

To explore the expression changes of proliferating cell nuclear antigen (PCNA) in oral normal mucosa and recurrent aphthous ulcers(RAU).

METHODS

The expression intensity and distribution of PCNA were examined with immunohistochemistry method in 15 cases of recurrent oral aphthous and normal oral mucosa.

RESULTS

In RAU, there was large amount of inflamed cells. In normal oral mucosa, the expression intensity of PCNA was significant higher than that in oral aphthous (P<0.05).

CONCLUSION

The inhibition of epidermal cells proliferation in RAU may be one of the mechanisms which one involved in RAU formation.