Acta oto-laryngologica · 2013
Surgery with postoperative radiotherapy for pN2 head and neck squamous cell carcinoma.
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Joo Young-Hoon, Cho Kwang-Jae, Park Jun-Ook, Nam In-Chul, Kim Chung-Soo, Cho Hyun-Jin, Kim Min-Sik
Аннотация
CONCLUSION: Factors that affected prognosis were T stage and extracapsular spread in patients that underwent primary surgery with postoperative radiotherapy for pN2 head and neck carcinoma.
OBJECTIVES: The purpose of this study was to examine treatment outcomes and define prognostic factors for pN2 head and neck carcinoma.
METHODS: A total of 209 patients underwent surgery with postoperative radiotherapy between 1994 and 2011. Primary tumor sites were the oropharynx (n = 70), hypopharynx (n = 48), larynx (n = 47), and oral cavity (n = 44). There were 21, 83, 60, and 45 patients with stage T1 to T4 cancers, respectively. The N stages were 20 N2a, 129 N2b, and 60 N2c.
RESULTS: The recurrence rate was 40% (83/209) over a mean observation period of 39 months. The 5-year disease-free survival (DFS), disease-specific survival (DSS), and overall survival (OS) rates in our cohort were 44%, 60%, and 56%, respectively. The presence of advanced T stage or extracapsular spread had a significant adverse effect on 5-year DFS, DSS, and OS rates according to Kaplan-Meier survival curves. Multivariate Cox regression analysis confirmed the significant association between 5-year DSS rate and advanced T stage (hazard ratio (HR), 2.20; 95% confidence interval (CI), 1.26-3.82; p = 0.005) and extracapsular spread (HR, 2.29; 95% CI, 1.24-4.21; p = 0.008).
OBJECTIVES: The purpose of this study was to examine treatment outcomes and define prognostic factors for pN2 head and neck carcinoma.
METHODS: A total of 209 patients underwent surgery with postoperative radiotherapy between 1994 and 2011. Primary tumor sites were the oropharynx (n = 70), hypopharynx (n = 48), larynx (n = 47), and oral cavity (n = 44). There were 21, 83, 60, and 45 patients with stage T1 to T4 cancers, respectively. The N stages were 20 N2a, 129 N2b, and 60 N2c.
RESULTS: The recurrence rate was 40% (83/209) over a mean observation period of 39 months. The 5-year disease-free survival (DFS), disease-specific survival (DSS), and overall survival (OS) rates in our cohort were 44%, 60%, and 56%, respectively. The presence of advanced T stage or extracapsular spread had a significant adverse effect on 5-year DFS, DSS, and OS rates according to Kaplan-Meier survival curves. Multivariate Cox regression analysis confirmed the significant association between 5-year DSS rate and advanced T stage (hazard ratio (HR), 2.20; 95% confidence interval (CI), 1.26-3.82; p = 0.005) and extracapsular spread (HR, 2.29; 95% CI, 1.24-4.21; p = 0.008).
Предметные рубрики MeSH
AdultAgedAged, 80 and overCarcinoma, Squamous CellDisease-Free SurvivalFemaleFollow-Up StudiesHead and Neck NeoplasmsHumansKaplan-Meier EstimateLymphatic MetastasisMaleMiddle AgedNeck DissectionNeoplasm StagingPostoperative CarePrognosisRadiotherapy, AdjuvantRepublic of KoreaRetrospective StudiesSquamous Cell Carcinoma of Head and NeckSurvival RateTreatment OutcomeYoung Adult