The use of tissue sealant in parotidectomy: a systematic review and meta-analysis.

OBJECTIVE

Drains are used post-parotidectomy to reduce seroma and haematoma formation. Tissue-derived thrombin sealant can enable a drainless procedure, allowing for an earlier discharge, less discomfort and a more cost-efficient method. This study aimed to assess whether tissue sealant improves wound-related outcomes in parotidectomy.

METHOD: A systematic literature review was performed using a standardised published methodology and custom database search strategy. A fixed-effect meta-analysis of the combined complications was conducted.

RESULTS

Thirteen studies were identified relating to parotidectomy procedures using tissue sealants, of which nine were included in the quantitative synthesis. Our analysis suggested a reduction in the complication rates, including haematoma and seroma, with drainless parotidectomy procedures involving tissue sealant use when compared with conventional procedures with post-operative drain use.

CONCLUSION

Fibrin sealant in parotidectomy may be used to facilitate a drainless approach, expediting recovery and offering better comfort to patients.