The Journal of dermatological treatment · 2011
Does isotretinoin therapy have any effects on electrocardiography, heart rate and blood pressure?
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Karadag Ayse Serap, Gumrukcuoglu Hasan Ali, Gunes Bilgili Serap, Ozkol Hatice Uce, Ertugrul Derun Taner, Simsek Hakki, Sahin Musa, Calka Omer
Аннотация
BACKGROUND: Isotretinoin therapy is associated with numerous adverse effects of various systems. Although some cases have been reported, cardiac side effects are rare following isotretinoin treatment.
OBJECTIVE: To investigate the effects of isotretinoin on the cardiovascular system.
METHODS: Seventy patients with acne vulgaris were enrolled in the study. The patients were treated with a dose of 0.5-1.0 mg/kg per day of isotretinoin. Screening for biochemical and hematologic parameters, heart rate, blood pressure and electrocardiographic parameters were done before treatment and after 3 months of isotretinoin treatment.
RESULTS: Heart rate, systolic/diastolic tension and electrocardiographic parameters (P-wave duration and QTc duration) were not statistically different before compared with after treatment.
CONCLUSION: As far as we know, there is no study researching the effect of isotretinoin on P- and QT-wave measurements in the literature. We found that isotretinoin did not affect P- and QT-wave measurement. Further studies with longer periods of follow-up are needed to understand the effect of isotretinoin on the cardiovascular system.
OBJECTIVE: To investigate the effects of isotretinoin on the cardiovascular system.
METHODS: Seventy patients with acne vulgaris were enrolled in the study. The patients were treated with a dose of 0.5-1.0 mg/kg per day of isotretinoin. Screening for biochemical and hematologic parameters, heart rate, blood pressure and electrocardiographic parameters were done before treatment and after 3 months of isotretinoin treatment.
RESULTS: Heart rate, systolic/diastolic tension and electrocardiographic parameters (P-wave duration and QTc duration) were not statistically different before compared with after treatment.
CONCLUSION: As far as we know, there is no study researching the effect of isotretinoin on P- and QT-wave measurements in the literature. We found that isotretinoin did not affect P- and QT-wave measurement. Further studies with longer periods of follow-up are needed to understand the effect of isotretinoin on the cardiovascular system.