Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association · 2026
Quality of life after endovascular thrombectomy: A multicenter, prospective, observational study.
СтатьяНаблюдательное исследованиеМногоцентровое исследованиеНазвание и аннотация: Перевод пока не подготовлен
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Karamchandani Rahul R, Yang Hongmei, Wang Liang, Strong Dale, Rhoten Jeremy B, Teli Katelynn J, Helms Anna Maria, Smith Sharon D, Brown Derica A, Adelman Elizabeth A, Patel Nikhil M, Defilipp Gary, Clemente Jonathan D, Bernard Joe, Stetler William R, Parish Jonathan M, Macko Lauren, Retelski Julia, Saba Kasser, Patel Shraddha, Tareen Tamour, Tarasaria Karan N, Bokka Satheesh K, Patel Harsh N, Wolfe Stacey Q, Guzik Amy K, Hines Andrew U, Williams Laura, Asimos Andrew W
Аннотация
INTRODUCTION: Patient-reported, health-related quality of life (QOL) metrics that capture elements not always accounted for by traditional scales are increasingly recognized as important measures but are still under-utilized. We studied QOL in a recent cohort of endovascular thrombectomy (EVT) patients.
METHODS: We conducted a multicenter, prospective, observational study of patients treated with EVT. The primary and secondary outcome measures were 90-day EuroQol 5-Dimension 5-Level index (EQ index, scores -0.573 to 1) and the Visual Analog Scale (VAS, 0-100), respectively. Spearman correlation was used to assess correlations between the EQ index and VAS with the 90-day modified Rankin Scale (mRS) and between each EuroQol domain and 90-day mRS. Linear regression was performed to identify factors associated with the outcomes.
RESULTS: 212 subjects (mean age 68.4 ± 14.7 years, median NIHSS 15 [interquartile range 10-20]) were included. Mean EQ index was 0.45 ± 0.42 and median VAS was 75 (interquartile range 60-90). Over 40% of subjects reported at slight problems or worse in each QOL domain and nearly 80% reported such problems in at least one domain. EQ index and 90-day mRS were strongly correlated in the full cohort (rs= -0.912, p<0.001) and in survivors (rs= -0.709, p<0.001). In the multiple linear regression analyses, premorbid mRS, cerebral blood volume index, and length of stay appeared to be associated with EQ index and VAS.
CONCLUSIONS: Ninety-day QOL measures may provide useful information as an adjunct to mRS scoring in selected stroke thrombectomy patients.
METHODS: We conducted a multicenter, prospective, observational study of patients treated with EVT. The primary and secondary outcome measures were 90-day EuroQol 5-Dimension 5-Level index (EQ index, scores -0.573 to 1) and the Visual Analog Scale (VAS, 0-100), respectively. Spearman correlation was used to assess correlations between the EQ index and VAS with the 90-day modified Rankin Scale (mRS) and between each EuroQol domain and 90-day mRS. Linear regression was performed to identify factors associated with the outcomes.
RESULTS: 212 subjects (mean age 68.4 ± 14.7 years, median NIHSS 15 [interquartile range 10-20]) were included. Mean EQ index was 0.45 ± 0.42 and median VAS was 75 (interquartile range 60-90). Over 40% of subjects reported at slight problems or worse in each QOL domain and nearly 80% reported such problems in at least one domain. EQ index and 90-day mRS were strongly correlated in the full cohort (rs= -0.912, p<0.001) and in survivors (rs= -0.709, p<0.001). In the multiple linear regression analyses, premorbid mRS, cerebral blood volume index, and length of stay appeared to be associated with EQ index and VAS.
CONCLUSIONS: Ninety-day QOL measures may provide useful information as an adjunct to mRS scoring in selected stroke thrombectomy patients.