American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2007
Candidate gene association study of insulin signaling genes and Alzheimer's disease: evidence for SOS2, PCK1, and PPARgamma as susceptibility loci.
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Hamilton Gillian, Proitsi Petra, Jehu Luke, Morgan Angharad, Williams Julie, O'Donovan Michael C, Owen Michael J, Powell John F, Lovestone Simon
Аннотация
Epidemiological evidence supports the existence of a possible link between type II diabetes mellitus (T2DM) and late-onset Alzheimer's disease (LOAD). Polymorphisms from candidate genes for T2DM were genotyped in a two-stage approach to identify novel risk factors for LOAD. One hundred fifty-two polymorphisms were initially genotyped in a case:control cohort: nine SNPs showed individual association with disease status under at least one genetic model, while an additional two SNPs showed a haplotype association. In a replication study, we confirmed significant association of SNPs within three genes--PPARgamma, SOS2, and PCK1--with Alzheimer's disease. In particular, our data suggest that the effect of variants within these genes might be influenced by gender.
Предметные рубрики MeSH
ATP-Binding Cassette TransportersAge of OnsetAgedAged, 80 and overAlzheimer DiseaseFemaleGene FrequencyGenetic Predisposition to DiseaseHaplotypesHumansInsulinIntracellular Signaling Peptides and ProteinsMalePPAR gammaPhosphoenolpyruvate Carboxykinase (GTP)Polymorphism, Single NucleotidePotassium ChannelsPotassium Channels, Inwardly RectifyingReceptors, DrugSex CharacteristicsSignal TransductionSon of Sevenless ProteinsSulfonylurea ReceptorsUnited Kingdom